Abstract:The central plains urban agglomeration is an important national strategy and it plays an important role in the national regional innovation system. Accelerating the integration and promotion of industrial technology innovation and diffusion in the central plains, and giving play to the synergy effect of regional innovation are of great significance for the economic rise of the central China. Based on the weighted Regional Industrial Technology Flow Tree (RITFT), this paper studies the industrial technology diffusion structure mechanism and the innovation synergy effect of the central plains urban agglomeration. Firstly, the measurement method of regional industrial technology correlation model was put forward from the perspective of probability. Based on RITFN, the modeling principle and method of RITFT were proposed to construct the RITFT of the central plains urban agglomeration. Then, the core structure mechanism of regional industrial technology innovation and diffusion of the central plains urban agglomeration was revealed from the distribution characteristics of industrial technology flows such as the main stream and tributaries. Furthermore, based on the analysis of the basic effect of individual industry loading, intermediary and diffusion, and the intensity and multiplier effect of technology spillover and absorption, this paper comprehensively evaluated the innovation synergy effect of the central plains urban agglomeration. The results show that the overall efficiency of technology diffusion cooperation in the central plains urban agglomeration is high, and industrial innovation has the characteristics of large cooperation within the province, small cooperation within the region, and strong spatial support complementarity. Finally, it is proposed to continuously strengthen the supply of regional innovation policies, improve the industrial collaborative innovation system of central plains urban agglomeration, and establish a new industrial innovation governance system of central plains urban agglomeration with the support of the comprehensive S T service platform of central plains urban agglomeration, so as to create a regional efficient innovation ecosystem.