Abstract:Science and technology innovation has emerged as a critical path for China"s social advancement, economic development, and national security protection. The paper takes 31 provinces in China from 2015 to 2020 as the research objects, and uses the SBM-Malmquist model to measure the efficiency of S&T innovation in China statically and dynamically; meanwhile, Selecting the top ten provinces of the comprehensive S&T innovation level index in the China Regional Science and Technology Innovation Evaluation Report 2021, and analyzing them with emphasis. According to the empirical findings, China"s total S&T innovation efficiency is poor, but there is an improving trend, with a trend of western > eastern > central regions; the growth of China"s S&T innovation efficiency benefits from technological progress and offsets the impact of declining technical efficiency; Shanghai and Beijing, which have the most comprehensive S&T innovation level indexes, respectively, have issues with duplicate S&T innovation investment and inadequate technical growth. We must focus on regional synergy, technical progress, and optimal resource allocation to achieve China"s scientific and technology innovation self-sufficiency and self-improvement.