With the rapid development of the economy, the cultural and creative industry has become a new focus of competition among regions. Talent is the core competitiveness of the development in culture and creative industry and further discussion on the development of regional talents has become a pressing matter of the moment. Based on defining talent’s connotation of cultural and creative industry, this thesis analysis the current talent’s status of cultural and creative industry in Guangdong province by linear regression and industry data combined with existing talent’s policy. Research shows that: demand has far outstripped supply of talents recently and it’s unreasonable for talent’s distribution of industry structure. In view of the existing problems, this thesis finally puts forward the countermeasures of the talents development.