Abstract:The study uses the number of the patents granted to characterize innovation capability, and investigates the spatial and temporal evolution the difference of innovation capability in Central Plains Economic Region by coefficient of variation, standard deviation and ESDA method between 1986 and 2013 Five conclusions are found as follows:(1)The absolute difference of innovation ability has the first slow after the fast widening trend in central China Economic Zone but relative difference decreased significantly after fluctuated in a relatively low level;(2) Annual Moran "s I did not change significantly in Central Plains Economic Area, While Moran "s I five-year period of mean increased;(3)The spatial structure of innovation ability is basically middle strong ends weak pattern along the Lianhuo Expressway, and innovation ability strong, mainly located in the traffic network intensive core city in Zhongyuan city group.(4) The space Cluster of innovation capability is growing, mainly for the increase of low concentration type;(5) Zhengzhou and Luoyang have been type high agglomeration,Nanyang has High and low concentration type, most of the economically underdeveloped areas is significantly low concentration,such as Zhumadian and Huaibei .