Abstract:State Key Laboratory system plays an important role in the technological innovation in our country, the question how to release its maximum performance has became the focus of research in this field. Based on Chinese paper sample database, with the mapping knowledge domains techniques, combined with Citespace visualization software, through quantitative analysis and visualization of existing research literature on research focus, research frontier research areas and representative research results, we mapped a series of mapping knowledge domains on the study status of State Key Laboratory System. On this basis, we given two key issues need to be resolved in our State Key Laboratory System: the synergy innovation among various State Key Laboratories; further focus of the research topics in State Key Laboratory System and the significance of its representative research results. This not only provides a theoretical foundation for deepening the research in State Key Laboratory System, but also points out the direction for enhancing innovative capabilities of our State Key Laboratory System.