先导化合物是现代新药研发的出发点。发现和寻找先导化合物有多种多样的途径和方法。虚拟化合物是一种基于受体结构的三维信息,采用计算机辅助药物设计技术,设计出的能与受体特异性结合的先导化合物。是否保护专利化合物的虚拟形式使用和由此产生的虚拟化合物是决定这一全新药物设计方法广泛普及和向前发展的关键所在。

The lead compound is the starting point of the development of modern medicine. There are a lot of methods in discovering and distinguishing the lead compounds. Virtual compound is based on three-dimensional receptor structural information, employs computer aided drug design methods to generate and optimize the lead compound. Whether or not to protect of the virtual form use of a chemical compound and virtual compound is the key factor to popularize and develop the de novo design.

战略-形象协同视角下国家知识产权形象建设研究