Abstract:The 18th National Congress of CPC proposed the strategy of innovation-driven development, which advocated innovation-driven development, instead of factor-driven development, as the long-term momentum of economic development. And the organic integration of culture and technological innovation coincided with the requirements of innovation-driven growth strategy. This paper thoroughly analyzed the mode and mechanism of the organic integration of culture and technological innovation. The organic integration mode was creatively divided into two categories, one is the collaborative integration model which promotes the collaborative innovation and development of culture and technological innovation industry, and the other is the interactive integration mode which creates new cultural formats. Meanwhile, the author analyzed the remodeling of the knowledge innovation chain, and then proposed the integration pattern of culture and technological innovation in accordance with the strategy of innovation-driven development.