Abstract:Since the 18th National Congress of CPC, the new government has put main focus into “stabilizing growth, adjusting structure, promoting reform”. Promoting SMEs to cooperate with large enterprises is just as one practical alternative to achieve economy growth and economic structural adjustment in regions. Based on the investigation of 21 key industrial clusters of Shaanxi province, combined with theory, This paper designs a cooperation mechanism system with “4-4-12” logical framework and constructs it completely. The “4-4-12” framework shows that a mechanism system which can promote SMEs to cooperate with large enterprises effectively should include at least 4 mechanisms and 12 concrete measures. The 4 mechanisms are: factors of production and environment support mechanism, ability improvement mechanism, motivation and evaluation mechanism, docking and collaboration mechanism. Among them, the first one is basic support, the second one is fundamental requirement, the third one is key power, the last one is important way to achieve cooperation. The 12 concrete measures are financial support measure, land support measure, organizational guarantee measure, environment guarantee measure, large enterprises radiation ability improvement measure, SMEs cooperation ability improvement measure, intermediary service ability improvement measure, motivation measure, evaluation measure, information docking measure, entities docking measure, achieving cooperation measure.