Abstract:Knowledge spillover affects the environmental protection industry cluster innovation strategic orientation and performance,so clarify the mechanism of action of environmental protection industry cluster will be beneficial to cluster innovation performance.This research constructs a conceptual model about the effect relationship between the environmental protection industry cluster innovation performance with several groups of variables such as knowledge spillover,and conducts an empirical testing to the enterprises in the Yixing environmental protection industry cluster.The research shows that,in the environmental protection industry cluster, knowledge spillover has a direct influence on the performance of environmental protection industry cluster innovation;Systematic knowledge ability has a regulating role in the process of knowledge spillover effect innovation performance,and innovation environment and enterprise network structure is a mediation role.