Abstract:The Professional town is an important organization form of supporting Guangdong regional economic development. To accelerate the professional town to industrial cluster innovation transition,is an important way to promote Guangdong economic innovation-driven、connotative development. Guangdong professional town to innovative industry cluster transition,the key is to improve theSinnovationSactivity, speed up the agglomeration of advanced production factors, build and improve the innovation chain, optimize the industrial layout, cultivate strategic emerging industry sectors, innovative facing the globalization of business model, improve the control force in critical parts of the global value chain, in order to enhance the professional town industrial competitiveness and sustainable development ability.