Abstract::Research integrity is not only the responsible of researcher, but also the responsible of the organization. Universities as the main research organization, have to emphasize the importance of the integrity and keep the high standard of research moral. Through the case study of the research integrity systems of university of Minnesota, analyze the importance of its measures, such as research integrity policy, management mechanism of research misconduct, education plans and so on ,how to encourage researchers have right values about research ,perform the responsible conduct of research and create good science moral atmosphere. Its experiences can provide useful reference to China Universities promote research integrity.