Abstract:Human capital investment risk and its evaluation of SME in science and technology is a hot issue for scholars and business at home and abroad currently. In the review on the basis of relevant theories, we design the survey questionnaire on human capital investment risk of SME in science and technology scientifically which passed the test of validity and reliability, and carry out the empirical research of Beijing 96 SMEs in science and technology. Through the way of factor analysis and analytic hierarchy process, combined with the actual situation, taking the internal investment risk analysis mainly, we define that the evaluation indicators system of human capital investment risk of SME in science and technology are consisted of six dimensions of 31 indicators forms including the risk of decision, loss, matching and using, agency, incentives and devaluation. We take further discussion on the weight of various dimensions and indicators. It provides a useful reference on the research development of human capital investment risk evaluation theory and practice of SME in Science and Technology