Abstract:This paper researches on the law of integrative development of culture and science from the perspective of social change and the universality of human civilization. There are four stages in this study. They are combination of ignorance in primitive society, interactive development in agriculture civilization period, symbiotic development in industrialization society and integrative development in post-industrial society. Cultures provide value orientation, environment, methods and incentive mechanism for science development. It plays an important role promote or inhibit. On the other hand, sciences provide material foundation, technical support, media and value orientation for culture. It plays an important role promote or inhibit through market.