Abstract:Knowledge has become the most important element of the enterprises’ development. we should focus on the element of knowledge and this will provide new ideas and approaches for the quality practice.By the structural equation modeling, this paper proposed a conceptual model and made some basic assumptions for the key elements of the knowledge-based quality management system. By putting the data came from valid questionnaires into the AMOS software and modifying the model, the relationship between key factors, the central position of leadership and the importance of the knowledge chain are decided. New ideas and theoretical basis are provided for enterprise to reform and build a quality management system.