Abstract:With the rise of metropolitan area with metropolis as the core, the new pattern of regional economy in our country gradually forms. Wuhan metropolitan area is the core area of the economic development of Hubei province and the important strategic fulcrum of the rise of central China, the improving of its science and technology innovation ability will be the key of promoting the whole region competitiveness, Radiating to drive the economic development of the whole province, and promoting the development of central China. This paper constructs the scientific and technological innovation evaluation indicator system that is composed of four kinds of primary indicators and 22 secondary indicators, and uses SPSS21 to accomplish empirical analysis and comprehensive evaluation of the science and technology innovation ability of Wuhan metropolitan area, and at the same time analyses the obstacles and development potential of its science and technology innovation ability construction.