Abstract:As the nation's top academic institutions, the establishment of former Academia Sinica is regarded as the originator of the National Autonomy Research, marks the beginning of China systematic scientific research, and the explanation final acceptance of modern western science in the China society. This paper aims to explore the social background of time and space of Academia Sinica established. From the historical contextualism point of view, in the background of Western learning, plays an important role in the emergence of occupation, groups of scientists led by Cai Yuanpei, political alliances, demand of national construction, saving the nation by science thought and national spirit. The combination of these factors for the establishment of Academia Sinica provides an opportunity.