Abstract:Ander the background of economic globalization, the implementation of “The Thirteenth Five-Year Guideline” will be with the help of implementation. The core of innovation-driven strategy is to emphasize that scientific and technological innovation is the driving force to promote China"s economic development and enhance the comprehensive national strength of strategic. The research on scientific and technological talents incentive mechanism adapted to innovation-driven during “the Thirteenth Five-Year Guideline” constructs incentive mechanism from two aspects of intrinsic motivation and extrinsic motivation, which conains six kinds of incentive mechanism such as career development motivation, work motivation, honor motivation, work atmosphere design motivation, remuneration and reward policy incentives and so on. The paper develops five kinds of safeguard mechanism containing the fair competition mechanism, sharing and cooperation mechanism, reasonable assessment mechanism, diversified development mechanism and the free flow mechanism.