Abstract:In recent years, as a rusult of the Mode of Industry-University-Research Institute Cooperation, some New Scientific Institutions have sprung up in Guangdong successively, such as kuang-chi institute of advanced technology and BGI-Shenzhen. They are becoming the new power of Innovation-driving-development, the new engin of Industrial Transition, and the new breakthrough of Scientific and Technical System Reform. According to main investors in infrastructure projects, the construction mode of them can be classified into five types: government-leading type, colleges and university-leading type, scientific research institution-leading type, company-leading type, social organization or Individual-leading type. The government should support them according to their advantages and disadvantages.