Abstract:The measures to reform government’s scientific breeding project were proposed on the view of China’s systematic reform of science and technology and on the view of government’s breeding development strategy, according to an example of Sichuan Crops and Animals Breeding Special Project (abbreviate CAB hereinafter). These results provided a reference both for the CAB in the 13th Five Plan and for the nationwide establishment and/or management of breeding project. Many problems of CAB were exposed, such as commercial breeding idea was not planed, management agent was not line with the national reform orientation of science and technology, management efficiency was low, and evaluation index was too subjective etc. This Breeding Project would be reformed deeply by the idea of market direction, collaborative research, industry convergence and personnel driving. Under this guidance, reform measures were proposed, which belongs to three areas of building professional management agent, market-determined allocation of science and technology resources, and enhancement of collaborative research by company, university and research institution.