Abstract:China is launching a new round of innovation of national science and technology (S&T) regime, with the core content is the reformation of management model of national research program. The international experiences of corresponding management model of medical research program can be served as the important reference. This study analyzed the characteristics of medical research program oriented by the government of U.S., ranging from organizational structure of management, strategic planning, categorical management and the procedure of the program, etc. The characteristics include: the quality of independence, concentration, high professionalism of medical research management bodies, integrity of program strategy planning with constant improvement, program establishment based on coverage of full chain of the research and industry, standardized management procedures, together with efficiency and transparency of management. China is urgent to establish concentrated, efficient, professional organizations for the professional management of medical research program, with the consideration of China’s actual conditions and the reference of international medical research program management characteristics. Each section of research industrial chain should be considered in program settings. Achievement transformation should be emphasized and program management procedure should be further regulated and specified, so as to promote managerial efficiency.