Abstract:The validity of index system directly affects the accuracy of the evaluation results. Based on the process of scientific innovation and regional innovation system, this paper establishes an original index system for scientific and technology innovation ability of university with qualitatively and quantitively screening methods. The conclusions lie on the following aspects. First, the multiple correlation method is used to delete the indicator which reflects repetitive information with other indicators. The gray correlation method is used to delete the indicator which is easily replaced by others, and it guarantees that the screened indicators have significant effect on results. Second, the distinguishing coefficient was calculated which improves the accuracy of gray correlation method. Third, the index system for the university scientific and technology innovation ability is established with 31 provinces, which contains 27 indicators. Fourth, the example shows that eventual inex system contains 90.7% information content of original index system.