Abstract:183: This paper establishes an evaluation index system, then using Grey Correlation Grade analysis theory evaluates regional science and technology innovation ability of Guang Dong province during 2000-2013. Empirical analysis indicates that the ability of regional scientific and technological innovation in GuangDong province shows a steady upward trend, and at the same time the problems can not be ignored ,such as low output efficiency of scientific achievements,insufficiency knowledge exchange , too slow promotion of Slaborer"s quality , low international competitiveness of products and so on . In order to enhance the ability of regional scientific and technological innovation in GuangDong province,at the last part of this paper puts forward countermeasures and suggestions accordingly.