Abstract:with the rapid development of global innovation network and knowledge economy, R & D industry as a strategic new industry plays an important role in industrial structure upgrading and transformation. The process of development of industrial agglomeration and industrial space layout evolution has its particularity of the internal mechanism and external mechanism, the R & D industry agglomeration for the evolution of regional economic development and geographical space plays an important role. The evolution path and mechanism analysis to deepen the research and development industry characteristics and evolution of fusion power, space distribution and morphology of the industry is of great significance, the R & D space industry cluster analysis has certain reference significance and practical value in promoting the rich spatial economics and new economic geography connotation and extension of research. According to the literature review, research industry spatial form and performance, research and development of industrial agglomeration factors, R & D industry agglomeration on regional spatial restructuring evolution path and mechanism analysis and other aspects of research content combined with the reconstruction of regional spatial agglomeration, agglomeration case and empirical analysis indicates that the technical innovation ability and R & D space agglomeration radiation influence in developed countries Europe and the United States and Japan's R & D industry, finally through the development of industrial agglomeration evolution path and R & D industry for regional space reconstruction led to the concentration of space-time process variation and regional spatial structure of regional geography entity to change, the result of the integration of R & D industry distribution and spatial reorganization, industry resources development industrial agglomeration regional innovation ability and development alliance the spatial response mechanism, development of industrial agglomeration leads to the agglomeration economy and external economy accelerating the spatial spillover effect form 4 aspects of system analysis research of industrial agglomeration mechanism for regional space reconstruction.