Abstract:Guangdong"s scientific and technological work with the international standards, with the market and the industry standards and advantages. Guangdong provincial Party Secretary in the research and Technology Department, pointed out that Guangdong to play this advantage, but also to the original innovation ability weak. In this paper, we analyze the problem of Guangdong province in promoting the development of original innovation, and analyze the problems in Guangdong Province, to clarify the scientific development ideas, to increase basic research investment, to integrate innovative resources, to enhance scientific research subjects innovation ability, to foster the introduction of high-level personnel, improve the scientific research system, create a good innovation environment, etc., and to provide countermeasures to enhance the original innovation ability in Guangdong.