Abstract:How to solve the environmental pollution problem in the process of china’s economic development relies on the organic coupling relationship between cleaner production technology innovation and end-of-pipe treatment technology innovation. On the basis of analyzed the coupling mechanism between the cleaner production technology innovation and end-of-pipe treatment technology innovation, the evaluation index system of the coupling degree between the cleaner production technology innovation and end-of-pipe treatment technology innovation was established, and an empirical analysis is performed to evaluate the coupling degree based on the Chinese provincial-level panel data during 2003-2013. Then, this paper discussed the spatial-temporal differentiation of the coupling relationship between cleaner production technology innovation and end-of-pipe treatment technology innovation from time dimension and space dimension. At last, the corresponding countermeasures and suggestions were given after analyzed the reason of the spatial-temporal differentiation of coupling relationship.