Abstract:The major factors of Guangdong High School innovation capability was discussed based on Cobb-Douglas Function by using the statistics data on science and technology of colleges and universities in Guangdong province. Human resource is the most important factor among those that affect the innovation capability. The positive effects of cooperation in production, study and research on innovation capability of colleges and universities in Guangdong province was found out, which was incardinated in patent of innovation and patent of utility model. The output elasticity of cooperation in production, study and research is 65% of that of human resource and 51% higher than that of government support. The innovation capability of colleges and universities in Guangdong province is determined by the government support. The spill-over effect in others colleges and universities in Guangdong province which has the weaker scientific research capability is more significant.