Abstract:Cross-regional public emergencies occur frequently in China, which results in significant impact, it becomes the urgent request of emergency management theory research and practical application to establish efficient across-regional emergency cooperation system. This paper clarifies the concept and connotation of knowledge coordination theory and cross-regional emergency cooperation system, analyzes the SoutstandingSproblems of across-regional emergency cooperation system in China from the perspective of knowledge collaboration, puts forward an across-regional emergency cooperation system framework based on knowledge collaboration theory, and analyses the main factors and operating mechanism. According to the research, across-regional emergency collaboration is a knowledge collaborative process of the emergency agent from different regions, the across-regional emergency cooperation system based on knowledge collaboration mainly includes: cross-regional emergency knowledge collaborative network, knowledge collaborative platform and some guaranteeSmechanisms, emergency collaborative network is the organization form to achieve the across regions emergency knowledge collaboration , knowledge collaborative platform provides technical support, the guaranteeSmechanisms are the "soft" environment to guarantee the system establishment and implementation.