Abstract:In this paper, the enterprise cooperative R D model is divided into horizontal and vertical cooperative R D, the selection progress of R D is divided into R D cooperation and production competition, combined with the method of AHP (Analytic Hierarchy Process) and FAHP (Fuzzy Comprehensive Evaluation), the influence factors of knowledge are added in the AJ model, this paper evaluates the influencing factors of enterprise knowledge cooperation development, analyzing the selection of cooperative R D model based on the factor of knowledge. The research shows that: when the knowledge influence factor is relatively small, the horizontal R D cooperation rate of return is less than the vertical R D cooperation rate; When the influence factors of knowledge gradually increase, the gap between the two is gradually narrowing, when the knowledge influence factor is relatively large, the horizontal R D cooperation rate of return is larger than the vertical R D cooperation rate.