Abstract:National Laboratory, State Key Laboratory of scientific research base as a source of innovation and new knowledge, new technology, new invention of the guide and source is training together high level scientific research personnel, an important platform for the results of independent innovation and core technology, is the embodiment of a country, an area of scientific research and innovation ability strong or weak a important index. Central eighth session of Fifth Plenary Session proposed "in-depth implementation of the innovation driven development strategy, to play a leading role in the overall innovation of the scientific and technological innovation, the implementation of a number of major national science and technology projects, set up a number of national laboratories in the areas of significant innovation". The of our province existing national research base construction were combed and summarized thoroughly analyzed, and the future especially "45" period of Guangdong Province scientific research base of system construction and puts forward some suggestions, especially to increase efforts to promote in the laboratory is leading to the construction of science research base, strengthen collaborative innovation, set up a group of high level scientific research innovation base and platform, the research system of the whole process of innovation chain to form a basic research, applied research, experimental development until the industry, Guangdong in the implementation of the innovation driven inevitable path of development strategy and an important guarantee.