Abstract:The entrepreneurs cluster’s innovation regarded as a new factor of production, analysising the entrepreneurs cluster’s innovation driven economic development mechanism with the aid of the Solow mode.Based on 2004-2013 dynamic panel data of 11 coastal provinces(citys),combined with the connotation of entrepreneurs cluster, analysising the effection of entrepreneurs cluster innovation on economic development from five aspects,the entrepreneur agglomeration degree,cluster’s openenss level,entrepreneurs’ innovation spirit,enterprising spirit and the entrepreneurs cluster’s internal structure hole .Research found that enterprising spirit of entrepreneur, level of entrepreneurs cluster openness, entrepreneurs agglomeration degree, the innovative spirit of entrepreneurs, entrepreneurs cluster internal network structure hole on the regional economic development presented sequentially decreasing significantly positive effect relationship.However,the indirect effects of entrepreneurs cluster innovation promoting regional internal capital agglomeration and total factor productivity found that entrepreneurs cluster internal network structure holes and capital accumulation have significantly negative correlation, the enterprising spirit and total factor productivity are negatively related, the level of entrepreneur cluster openness towards capital agglomeration and total factor productivity did not show a significant relationship.