Abstract:Vulnerability research paradigm is applied to science and technology evaluation field, science and technology vulnerability’s connotation is analyze based on vulnerability’s connotation, evaluation indicator system is built from sensibility and recoverability, Shandong province science and technology vulnerability in 2000-2014 is evaluated, The results show that: ① Sensibility index kept at a lower level and the change trend was not pronounced. ② Recoverability index presented a increasing trend. ③ Vulnerability index experienced an evolution process of “rise, decline and rise” and the major trend was decline, it explained science and technology’s negative influence and damage probability was low. The regulation measures were put forward from reduce science and technology vulnerability and science and technology restorative.