Abstract:High and new technology industry is a highly intensive industry of knowledge capital, and its innovation performance, technology spillover and transformation and upgrading have been a hot topic in the academic field. This article put the human capital, development capital, innovation environment, foreign knowledge capital into the same model, and test the impact of international knowledge capital on the transformation and upgrading of Yangtze River Delta and other seven regions high-tech industrial, the results show that:the local innovation effort and innovation ability is the basic power of high-tech industry upgrade; the impact of international knowledge capital from technology import on upgrade is not obvious; while the impact of international knowledge capital from new export channels is conducive to promoting high-tech industry upgrading; international capital knowledge spillover is an important factors of high-tech industry in Bohai and the Yangtze River Delta region to upgrade, but in other areas the international knowledge capital is not significant factors for the high-tech industrial upgrading