Abstract:Regional development ability is the core of the area economic development, however, entrepreneurship is the internal motivation to enhance the capacity of regional development.Based on the connotation definition of entrepreneurship, rely on Qian Xuesen"s "Metasynthetic Wisdom" , this paper establishes the thinking paradigm of entrepreneurship wisdom, which can be divided into two dimensions: lower level of entrepreneurship ,high level of entrepreneurship. At the same time, the article systematically discusses the regional entrepreneurship evolution logic from individual dimension, enterprise dimension and social dimension,Aimed at providing a new perspective about further research on entrepreneurial spirit, which make entrepreneurship can play an important role in the process of regional sustainable development.