Abstract:In the national provincial science and technology department in charge of government WeChat ,selecting "Guangdong Science and Technology" as an example, the article introduces WCI influence index and AHP method to construct a logical framework . Points out that the provincial department in charge of science and technology from the dimension of seven WeChat public platform of the main problems in the spread of influence, then from the five dimensions of provincial science and technology department in charge of government WeChat operation management are proposed as follows: In the aspect of operational content management, it should change the way of thinking to enhance government WeChat affinity; In the brand activities, creating online and offline brand activities through government WeChat as the sole entrance; In the information supply channels, making full use of ministries platform resources to build a matrix of information supply channels; In the spread of the form, enriching the forms of communication to enhance the user experience; In the background security ,building a security system to strengthen the establishment of comprehensive strategic partnership.