Abstract:With the rapid development of information technology, cloud computing, Internet of things, big data, the Internet has profoundly changed the traditional logistics model, the construction of regional logistics system has been far-reaching impact. How to achieve efficient operation of logistics through resource sharing, to become a big data era of scientific and technological innovation in the context of the construction of regional logistics system to solve the problem. Based on the construction of the regional logistics system of Guangdong, Hong Kong and Macao as the research object, this paper analyzes the importance of coordinated development in the process of the construction of regional logistics system and the effect of scale economy. In combing and extensive research of literature, that affect the construction of the main factors of Guangdong, Hong Kong and Macao regional logistics system, from both the government and the enterprises value chain resources collaborative perspective, that government policy conditions and logistics enterprise activity conditions complement each other, Guangdong, Hong Kong and Macao region logistics system construction is product collaborative government policy and logistics enterprise activity. Based on this, from the government level, enterprise level, science and technology management and collaborative innovation level put forward targeted countermeasures, research results on the construction of Guangdong, Hong Kong and Macao regional logistics system has a positive guiding significance.