Abstract:In the context of promoting structural reform of the supply front , regional innovation and regional information are the important forces for adjusting the regional industrial structure, promoting economic and social development. Through calculating the regional innovation and the informatization evaluation index of Silk Road Economic Belt nine provinces (autonomous regions and municipalities) from 2006 to 2014,the paper constructs the coupling coordination model ,then calculates the coupling coordination degrees between the regional innovation and the informatization ,at last ,measures the change of differences in the degrees between regional and intra regional .The result suggests that: (1) The regional innovation level and informatization level of each region in the Silk Road Economic Belt is not high, and the regional innovation lags behind the regional informatization; (2) The developments of regional innovation and regional informatization in various regions are in the high levels of coupling resonance state, but when considering the development level, although the coupling coordination degrees improved year by year., but the developments are uneven, the degrees have not yet reached the quality state of coordination during the research period; (3)The differences in the degree of the whole Belt expanded at first and then shrunk, and the regional differences ,mainly formed by the northwest area degree differences, contributed most to the overall differences. Based on the analysis and explanation of the results, some policy suggestions were presented.