Abstract:Science and technology major projects are large innovation activities with clear objectives and a specific direction. The implementation process of science and technology major projects involves the key core technology development, important product or major (demonstration) engineering construction. It has great influence on improving the ability of independent innovation and building an innovative country. Theory, system theory, based on the theory of project management, project organization and management and other related management theory and knowledge, to organize and implement the process for major projects of science and technology to carry out in-depth study. It references the success of the implementation of major projects organization and management experience, and construction of major projects of science and technology management mode suitable for China"s national conditions. In order to promote our country science and technology major projects to further improve the management level and management efficiency.