Abstract:Abstract: Research method of urban innovation function index and innovation location entropy, Making use of the economic data of the manufacturing industry of the 5 cities of South of Jiangsu and China's patent information service platform of South of Jiangsu manufacturing industry patent authorization data, Analysis of the innovation system and the evolution of the division of labor in South of Jiangsu urban manufacturing industry in 2007, 2010 and 2013. Results found: The innovation function of urban manufacturing industry in South of Jiangsu has experienced the innovation polarization in 2007 and the innovation diffusion effect in 2010, Gradually formed in the center of Suzhou, Nanjing, Wuxi sub center three tower structure. South of Jiangsu innovation center, Nanjing constantly differentiate manufacturing innovation functions, South of Jiangsu city manufacturing sector innovation division of labor. In view of the above research law, Put forward Suzhou as a regional Integrated manufacturing innovation center and optimize the structure of the South of Jiangsu manufacturing industry innovation division of labor.