Abstract:With the analysis on demand and supply of resource elements in Guangdong science and technology business incubators, and the research on mechanism of incubators cohesion and coupling, this paper propose some concepts,such as Intrinsic Cohesion, Extrinsic Cohesion, Transverse Coupling and Longitudinal Coupling. and make comparison between them,and propose two typical paths to enhance cohesion and coupling degree. On this basis, bringing forward relevant countermeasures about government administration sections strengthen constructions towards Guangdong science and technology business incubators, in terms of six aspects, support incubators service capability promotion, encourage the combination of incubators and science and technology service institutions, encouragement towards multimember corporations, co-incubation leagues construction, strengthen incubation chains docking and upgrade government management efficiency etc.