Abstract:From the connotation of the innovation and the relevant background, author summarizes the meaning of knowledge innovation and technology innovation and gives a bionic technology innovation and knowledge innovation based on structure of DNA, elaborates the meaning of their bases in detail, then from a double helix point of view author researches on relationship between technological innovation and knowledge innovation. Author establishes the double helix model of the interaction between them, which process is simulated in detail. Finally, the foundation, nature and characteristics of the innovation model are explained based on the double helix model structure of technology and knowledge in detail, so as to reveal the operating rules of innovation more deeply.