Abstract:The paper studies the intellectual property protection mechanism of government- industry-academy collaboration databases from the perspective of project management. It proposes intellectual property management strategies in response to the five phases of database project management. Taking Shanghai Genome Material database as an example, it elaborates in detail on database intellectual property strategy deployment in the project initiation phase, database intellectual property planning in the project planning phase, database intellectual property protection in the project execution phase, database intellectual property management in the project monitoring phase, database intellectual property application in the project closure phase, and therefore forms a set of systematic and comprehensive intellectual property protection mechanism for database project under the collaboration of government, industry and academy.