Abstract:The main task of the current poverty alleviation in China is to make a better live for poor population, by analyzing characteristics of China’s poverty alleviation history. It is no doubt that science and technology is going to play an important role in supporting blood-making poverty alleviation in the 13th Five Year Plan of China. There are five historical opportunities existed for Poverty Alleviation by Science and Technology (PAST), including supply-side reform, innovation and entrepreneurship policy, system reform of science and technology, internet plus strategy, and the so called five developmental conceptions proposed by Chinese central government. However, the present poverty alleviation project management system is not met the needs of PAST’s role as a leading force in China’s poverty alleviation in the 13th Five Year Plan, it is thus urgent to reform this system. The goal of PAST is to create industry, talent, service, and mechanism for poor areas, according to results of this study. A new idea managing projects of PAST is proposed to simplify processes, facilitate grassroots, and pay more attention to people and performance. Under the guide of this idea, an innovative project management system of PAST is reconstructed, and its main contents are classification of project, specifically-transferred financial payment, and reform of accounting subjects. The highlights of these subjects are depicted by four aspects: 1) improve ratio of indirect expenditures; 2) ease restriction of labor and equipment costs; 3) create fees to repair and renovate infrastructures, costs for introduction of new technology and varieties, and car rental fees; 4) cancel publication fees, expenditures for international cooperation, and fuel costs for specific laboratory apparatus. The new institutional framework is in line with the overall reforming orientation of science and technology system in China, aiming at helping management of PAST projects nationwide.