Abstract:Throughout the development of high-tech industry zones in Guangdong province for more than 20 years, it can be seen that the vitality of its innovation has increased significantly, the size of enterprises has been growing rapidly, industrial agglomeration and upgrading has become an important engine of regional economic development. This research is on the basis of the statistical data, carries on the analysis to the above 23 provincial-level high-tech Development Zone features from the aspects of economy, industry, science and technology, enterprises face, and found problems in the process of its development, and put forward targeted countermeasures and suggestions, decision-making reference for relevant department.