Abstract:Abstract: The US Office of Research Integrity (ORI: Office of Research Integrity) is the most well-known scientific research management institution in the world, which is the most famous,professional and authoritative, it can be rated as a model of governance around the world. Since its inception, ORI has undergone a continuous process of development, increasing influence. So far, no scholars have made a comprehensive and systematic study on ORI. This paper explores the historical evolution, management system and operation mechanism of ORI, and tries to make a comprehensive, systematic and complete interpretation of this special institution of scientific misconduct.