Abstract:In the condition of limited resources for innovation, improving the innovation efficiency of high technology industry of the Yangtze River Economic Zone is to promote the "2025 China manufacturing" and "The Belt and Road" strategy development .Based on the provincial panel data,using CCR and super efficiency model to measure the efficiency of nearly six years,this paper finds that the whole hi-tech industry innovation efficiency level is higher and larger about the gap between provinces in Yangtze Economic Zone. Then the dynamic comparative study of innovation efficiency has been done by using Malmquist-DEA model.The result shows that the growth rates of TFP value are always larger than 1,in addition to Yunnan,and the technological progress is the main driving force to promote innovation efficiency growth rate. The Tobit model based on panel data has been developed to study the effect of the efficiency at different factors,the result shows that government expenditure,enterprise scale,ownership,foreign direct investment have significant influence on the efficiency of innovation.finally,using social network analysis method,it finds connection between the main network is not close,and connection of the eastern region is higher than central and western in Yangtze Economic Zone. Finally, the paper puts forward some countermeasures.