Abstract:The megaproject team is a knowledge aggregation which constituted by project subjects through certain rules .As the main completer of the megaproject, The megaproject team gets through the continuous knowledge learning and memory to eventually solve the project problems.In this paper, The features and connection of the megaproject team knowledge,learning and memory are discussed based on the knowledge creation model. Then this paper establishes a logical model of the megaproject team knowledge,learning and memory from the perspective of biological immunity and the analogy between the megaproject team and the immune system. This model change that the issues of the megaproject team knowledge-learning-memory are often discussed independently and fragmentally, At the same time, it also reflects a complete knowledge management chain. Finally, the suggestions of how to enhance the knowledge management of megaproject team are put forward from the perspective of biological immunity.