Abstract:This paper selects NIS as the research object, reviews and studies researchs on NIS in order to provide a scientific basis for the construction of China’s innovation system. The findings include: first, innovation system approachs are more diversified, but the “national” boundary of innovation system is still significant. second, the topics and contents of this field witness a sustained expansion and evolvement. Moreover, its research area is turning from OECD country to less development country. We argue that the research of internationalization of NIS is a key direction. we suggest that the future study of NIS should further explore new theories as well as interdisciplinary approaches. It is also important to study of internationalization of NIS, in particular combining the Global Value Chain and the Innovation System perspectives, and develop the multi-level framework to integrate various innovation system.