Abstract:The development of manufacturing industry is inseparable from informatization, globalization and greenization. Under the influence of informatization, globalization and greenization development, this paper constructs the conceptual model of manufacturing industry upgrading to the low-carbon technology breakthrough innovation, then it conducts empirical testing by using SEM. The result shows that the development of manufacturing industry has played a positive role in the process of industrial upgrading promoting low-carbon technology breakthrough innovation. However, industrial structural upgrading has a negative impact on informatization development, industrial transformation and upgrading has a negative impact on globalization development and the role of greenization development promoting low-carbon technology breakthrough innovation is not obvious.