Abstract:Knowledge - based talents are closely related to the development of industrial clusters. It’s been analyzed that the knowledge - based talent movement has both promoting and hindering effect on industrial cluster development through study on the current situation of knowledge - based talent flow and industrial cluster development. The life cycle theory is used to discover the influence of different stages of industrial clusters development on attracting and rejecting the knowledgeable talents. In the process of the interaction between knowledge-based talents and industrial clusters, some problems, such as lacking of cooperative consciousness, the imbalance of regional development, lacking of innovation ability and the imperfection of the talent market, arise. To solve these problems, the idea of intensifying propaganda to establishing win-win consciousness, overall planning to promote regional development in an all-round way, promoting institutional reform to strengthen the capability of independent innovation, and taking measures to guide and perfect the talent market.