Abstract:With globalization and specialization becoming more and more complete today, knowledge has become a kind of sharp "weapon" carrying great potential in enterprise development. In the innovation network, the cooperation of enterprises has became the cooperation based on knowledge sharing.。In contrast to other forms of enterprise cooperation, the implicit and explicit income, implicit and explicit costs need to be balanced in the cooperation of enterprises that hold knowledge innovation. Adopting the method of game theory, this paper quantizes the benefit and risk carried by the knowledge, increases the non-monetary earnings, and considers the trust has a big effect on the extra costs. Then, this paper analyzes whether enterprises can collaborate and how to form cooperation between them. Finally, this paper constructs the dynamic model of the innovation game of both firms, and tries to seeking evolutionary stability strategy.